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Shaking introduces air bubbles, which means oxygen exposure and potential foaming

In research it activates melanocortin receptors MC1R (pigmentation), MC3R/MC4R (appetite, libido)

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In vitro barrier models using Caco-2 cells (gut epithelium) or brain endothelial cells could be employed to test the hypothesis that microbiota metabolites, such as butyrateeither administered directly or derived from patient-derived fecal microbiota culturescan strengthen epithelial and endothelial barrier function and reduce oxidative stress [40]

9 Most retrospective epidemiological studies tend to underreport and underestimate the true incidence of statin-induced liver injury