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Retatrutides Phase 2 monotherapy weight loss (~24.2% at 48 weeks) is numerically larger than cagrilintides (~10.8% at 26 weeks), but those come from different trials, durations, and doses, and cagrilintides strongest data are as the CagriSema combination

doi: 10.1126/science.1156906

Galderisi M, Caso P, Cicala S, De Simone L, Barbieri M, Vitale G, de Divitiis O, Paolisso G: Positive association between circulating free insulin-like growth factor-1 levels and coronary flow reserve in arterial systemic hypertension

Our data thus far show that 5FU drives increased mitochondrial biogenesis to address a functional requirement for increased mitochondrial ETC metabolism

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