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GSH depletion significantly decreased the hepatic expression of Srebf1 and its direct downstream effector stearoyl-CoA desaturase ( Scd1 ) under both chow and HFD conditions (Figure 3, AC), indicating suppressed lipogenesis

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Reviews To Read February 2026 Published in JAMA Psychiatry by Mehdi Farokhnia and Lorenzo Leggio of the NIDA IRP Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section