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M., Duman, H., Rocha, J

Chemical agents targeting GLSs have been studied, and CB-839, 968, and BPTES have been found to exhibit tumor-specific antiproliferative effects 199

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Ozempic and other GLP-1 receptor agonists dampen mesolimbic dopamine signaling, reducing reward salience and drug reinforcement across addictions

While the results were encouraging, by the mid-1990s Holst and Carolyn Deacon, a physiologist at the University of Copenhagen, confirmed an earlier finding by Rolf Mentlein, Baptist Galllwitz and Wolfgang Schmidt based at the University of Kiel in Germany who had found in 1993 that GLP-1 did not last long in the body because it was broken down in minutes by dipeptidyl peptidase-IV (DPP-4), an enzyme found in numerous tissues and in the bloodstream (Mentlein, Galllwitz, Schmidt