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Contraindications and caution categories include active malignancy, pregnancy and breastfeeding, pediatric use, uncontrolled diabetes, and patients on medications or peptides with overlapping mechanisms where stacking has not been evaluated

doi:10.1111/j.1532-950x.2003.00515.x Pickart L, Margolina A

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Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity