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Tirzepatide was FDA-approved in 2022 initially for type 2 diabetes management, and then also for weight loss

Pharmacologically, only short-acting GLP-1RAs demonstrate a marked reduction in gastric emptying (156), while chronic activation of GLP-1R results in a waning effect on gastric emptying due to tachyphylaxis

Semaglutide-based products have achieved widespread adoption across both diabetes and obesity treatment settings, supported by growing physician confidence and favorable clinical guidelines

CNS, central nervous system

These drugs can lead to significant weight loss, around 10% of body weight within six months, but may also cause side effects