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Neuroinflammation has been difficult to assess with specificity and sensitivity, and advances in molecular imaging, particularly PET with radiotracers that bind the 18kDa translocator protein (TSPO), have made it possible to visualize and quantify these neuroinflammatory processes in living brains ( Figure 2C ) (142)

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Because retatrutide is potent and multi-acting, it will likely require stricter screening and monitoring than older medications

Quantification and statistical analysis GraphPad Prism v.10.0 and Rstudio (v.2023.09.1) were used to perform statistical analysis

Scrambled siRNA and siRNA targeting the ET-1 receptor were purchased from Santa Cruz Biotechnology, Inc