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Mechanism in research literature NNMT (nicotinamide N-methyltransferase) catalyses the methylation of nicotinamide using S-adenosylmethionine (SAM) as the methyl donor, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine

doi: 10.1100/tsw.2004.71

35 In MASLD, insulin resistance in both liver and adipose tissue disrupts these pathways, exacerbating steatosis and inflammation

Hence, the existing neuronal damage in MSG-intoxicated group may be responsible for in the observed depletion in brain neurotransmitter levels, including DA, NE and 5-HT in this group