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Immunohistochemistry (IHC) images were performed utilizing an E2-specific antibody recording the colocalization with a SNAP-tagged GLP-1R after a time-dependent fixation

B1a cells express germline-encoded natural IgM with little to no affinity maturation, resulting in IgM that is broadly specific and low-affinity for many self-antigens (including oxLDL)

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Most notably, the patients enrolled in LEADER had chronic cardiovascular risk (either a pre-existing cardiovascular condition or a high risk for cardiovascular disease), while only those individuals who were within 180 days post-acute coronary event and, hence, at the highest risk of a further cardiovascular event, were included in ELIXA