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Triggering vagal afferents, GLP-1 mediates signaling from gut to brain with anorexigenic effects and via nerve terminals in the hepatoportal region, it can affect metabolic functions in the liver (15)

For those seeking remarkable transformations, combining them with lifestyle changes such as a balanced diet and regular exercise is necessary

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Contrave (naltrexone and bupropion) is an oral combination medication that targets brain pathways involved in cravings and reward

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