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A diverse bacterial community is capable of producing a broad spectrum of functional metabolites that exert systemic and metabolic effects on the host, thereby shaping what is recognized as the gut microbiome (8, 9)

Gut Liver 11 (2), 173188

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However, nucleic acid therapeutics are inherently susceptible to degradation, require stringent dose control to minimize off-target effects, and typically modulate only a single pathway, such as VEGF upregulation-limiting their therapeutic scope