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Psychiatry 12, 669089

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A major barrier is their poor bioavailability, attributed to rapid metabolism, limited systemic retention, and restricted penetration of the bloodbrain barrier, necessitating the development of advanced delivery platforms such as nanoformulations, liposomes, or prodrugs to enhance central nervous system targeting (Iqbal et al

D-retro-inverso refers to a peptide made with D-amino acids in reverse sequence order