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The studies were variably adjusted for potential confounders including age, reproductive history, smoking status, BMI, breastfeeding, socioeconomic status, and family history of BC (Table 11)

The clinical case rests on two trials, BRUIN CLL-313 and CLL-314, that Lilly says were the first Phase 3 studies to test a non-covalent BTK inhibitor, a targeted oral drug that blocks a protein driving cancer-cell growth, in previously untreated CLL patients

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Results from the SURPASS and SURMOUNT series trials suggest significant efficacy in lowering blood glucose (with reductions of up to 2.24%) and in weight loss (up to 11.2 kg)

As your body adjusts to the medication, tiredness should fade