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While we recognize that we intend to release the updated participant lists for subsequent ASM performance years, which could include new clinicians to the model, at least 6 months prior to the start of a given ASM performance year, we believe that clinicians who practice within a mandatory geographic area and would potentially be eligible for mandatory participation would likely be familiar with the model given our planned outreach and communication strategies
Research protocols using 5-Amino-1MQ typically administer 50100mg daily via subcutaneous injection, based on human equivalent dose scaling from rodent studies where 10mg/kg bodyweight produced measurable NNMT suppression and increased NAD+ bioavailability
