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Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302

Retatrutide is not approved by the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA) and remains under clinical investigation

Shanmughapriya S et al (2015) SPG7 is an essential and conserved component of the mitochondrial permeability transition pore

In addition to maintaining hepatic metabolic homeostasis, AMPK activation has been reported to promote mitochondrial function and suppress endoplasmic reticulum (ER) stress 22

Since the peptide promotes blood vessel formation, questions arise about whether it could support tumor growth in people with existing cancers