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Song JX, An JR, Chen Q, Yang XY, Jia CL, Xu S, et al

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One placebo-controlled trial, called ATTAIN-MAINTAIN, followed adults who had previously completed the SURMOUNT-5 obesity trial, a randomized controlled study evaluating whether tirzepatide, the active ingredient in Zepbound, led to greater body weight reduction versus semaglutide in adults with obesity

Further studies are needed to determine how much of the benefit comes from weight loss versus the medication itself, Thompson noted