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The action is largely transcriptional, which is rate-limited by protein synthesis rather than receptor availability

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doi: 10.1530/eje-10-1026 193 HuangZRoseAHHoffmannPR

Melanocortin and Metabolic Peptides: A Different Research Category Entirely Peptides like Melanotan II (melanocortin receptor agonist) and GLP-1 receptor agonists like Semaglutide and Tirzepatide act through completely different receptor systems melanocortin receptors and GLP-1 receptors respectively with no mechanistic overlap with BPC-157