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Tirzepatide acts on both GLP-1 and GIP receptors, and data suggests patients experience greater weight loss with it

Note: If you have a sensitive stomach, it is perfectly fine to take these with a light snack

(2) produce H 2 S which could induce hepatic FXR and inhibit CYP7A1 expression and bile acid synthesis, (3) these collectively, modulate hepatic bile acid metabolism to produce more hydrophobic bile acids due to increased DCA and decreased MCA, which increases HI of bile acids facilitating intestinal cholesterol absorption (4) resulting in hepatic cholesterol overloading, and thereafter (5) promoting canalicular cholesterol secretion into bile and gallstone formation

5 Gatto, A., Liu, K., Milan, N., & Wong, S

These include smoking, excessive coffee or alcohol consumption, diabetes, rheumatoid arthritis, thyroid disorders, coeliac disease, Crohns disease, obesity, physical inactivity, chronic stress, and certain long term medications such as proton pump inhibitors and corticosteroids