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doi: 10.2337/dc22-1127 20

[7] Clinicians should exercise extreme caution in advanced chronic kidney disease or sarcoidosis, tuberculosis, and other granulomatous disorders where extrarenal 1-hydroxylase activity can generate excess calcitriol and precipitate hypercalcaemia even at modest serum 25-hydroxyvitamin D concentrations

We're trying to make tablet-based small molecules back then, and they were just not drug-like enough

Persistent or severe digestive symptoms, dysphagia, or signs of pancreatitis require prompt medical assessment and should not be dismissed as routine side effects

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