Abbreviations HA: hyaluronic acid, a natural extracellular matrix (ECM) component GSH: glutathione, a key intracellular antioxidant ROS: reactive oxygen species, molecules involved in oxidative stress ECM: extracellular matrix, the structural scaffold surrounding cells CD44: cluster of differentiation 44, a cell surface receptor for HA HMW-HA: high-molecular-weight hyaluronic acid, with anti-inflammatory properties LMW-HA: low-molecular-weight hyaluronic acid, often pro-angiogenic or pro-inflammatory TLR: toll-like receptor, involved in innate immune signaling NF-B: nuclear factor kappa-light-chain-enhancer of activated B cells, a transcription factor regulating inflammation IL-10: interleukin-10, an anti-inflammatory cytokine TGF-: transforming growth factor-beta, a cytokine involved in immune regulation and wound healing Nrf2: nuclear factor erythroid 2related factor 2, a regulator of antioxidant defense pathways HO-1: heme oxygenase-1, an enzyme induced under oxidative stress GSH-Px: glutathione peroxidase, an antioxidant enzyme that reduces hydrogen peroxide M1: pro-inflammatory macrophage phenotype M2: regenerative, anti-inflammatory macrophage phenotype ADSCs: adipose-derived stem cells, used for regenerative therapy VEGF: vascular endothelial growth factor, promotes angiogenesis MOF: metalorganic framework, a porous material used in drug delivery PEI: polyethylenimine, a polymer used for gene and drug delivery AgNP: silver nanoparticles, used for their antimicrobial properties BLE: Bluetooth Low Energy, used in wearable biosensor communication GelMA: gelatin methacryloyl, a photocrosslinkable biomaterial EMT: epithelialmesenchymal transition, a biological process in cancer and tissue repair GMP: good manufacturing practice, standards for pharmaceutical and medical device production References Mamun AA, Shao C, Geng P, Wang S, Xiao J
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Supplementing this natural response with additional OGP may amplify the healing process
Thus, acetyl glutathione is the best supplier for reduced glutathione with oral intake
Treatment horizons Given the in vitro studies showing that antioxidant supplementation of peritoneal and follicular fluids mitigates damage to human sperm, oocytes and embryos, it is logical to predict that in vivo treatments with antioxidants will improve parameters of fertility in endometriosis
