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SNX1 and SNX2 jointly induce the formation of spherical vesicles in liposome tubulation assays In Arabidopsis , six SNX-like proteins have been identified

They cannot adequately explain several key phenomena: cognitive decline in CVD patients without obvious cerebrovascular lesions, indicating the critical role of non-vascular factors

A variety of approaches have been evaluated but with limited success, including stem cells, growth factors, cytokine modulators, antimicrobial and anti-inflammatory drugs, matrix metalloproteinase regulators, angiogenic stimulators, extracellular matrix promoters, and several phytopharmaceuticals