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Further loss after a reduction can undo the results, so timing the procedure matters

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The study authors said they hope their findings will empower patients to monitor for early symptoms.

However, the therapeutic utility of doxorubicin is undermined by its dose-dependent cardiotoxicity, possibly arising as a result of futile redox cycling, with NADH dehydrogenase within the mitochondria proposed as the most likely site of anthracycline reduction 9,10