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GLP-1RAs are promising for treating obesity due to their effects on appetite and food intake

The substantial placebo-controlled trial registered adults unaccompanied by diabetes

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For injectable GLP-1 medications: Timing requirements : For once-weekly injections (semaglutide [Ozempic, Wegovy], dulaglutide [Trulicity], exenatide extended-release), administration can occur at any time of day, with or without food

The available human data suggests significant regression toward baseline after discontinuation, which raises mechanistic questions about whether the compounds produce structural metabolic change or ongoing pharmacological modulation