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[123] underlines engagement, ethics, and representativenessconcerns we operationalise by quantifying annotation practice and agreement, documenting dataset biases, and proposing concrete reporting and linkage practices (e.g., consistent use of MedDRA coding) to translate social-media signals into pharmacovigilance workflows

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Thats because taking spironolactone with food substantially increases the bodys absorption of the drug and the plasma concentration of its active form