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By contrast, real-world persistence drops off a cliff fairly early on

In low oxygen situations (hypoxia, ischaemia) lactate increases several-fold as its conversion from pyruvate in the lactate dehydrogenase reaction is essential to regenerate NADH needed to maintain glycolysis [59]

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In order to give a strategic roadmap for mitochondria-based interventions in the era of precision medicine, we offer a critical evaluation of the translational gap in metabolic medicines, such as GLP-1 RAs and mitophagy inducers, beyond a comprehensive overview of energy pathways