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In November and December 2025, the two largest clinical trials ever run with a glucagon-like peptide-1 receptor (GLP-1R) agonist in a neurodegenerative disease reported their results

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MT-1 was originally developed as a potential therapeutic agent for conditions like erythropoietic protoporphyria (EPP) and other photosensitivity disorders, where increased melanin production could reduce UV-induced damage

Ghrelin secreted in the stomach mucosa circulates to the brain and crosses the blood-brain-barrier