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BRIN-BD11 cells were used throughout this study for their well characterised responses to multiple stimuli, cell culture based convenience and their established intact response to GLP-1R activation both in terms of cAMP and resulting stimulated insulin secretion 36, 37

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Zepbound demonstrated 20.9% mean body weight reduction in SURMOUNT-1 at 15mg surpassing semaglutides 15% benchmark and establishing dual GIP/GLP-1 agonism as the dominant next-generation obesity mechanism