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Funding Ministerio de Ciencia, Tecnologa e Innovacin (Colciencias), Ministerio de Educacin Nacional, Ministerio de Industria, Comercio y Turismo e ICETEX (7922017 2a Convocatoria Ecosistema CientficoColombia Cientfica para la Financiacin de Proyectos de I + D + i), and Vicerrectora de Investigaciones, Pontificia Universidad Javeriana, Bogot D.C., Colombia (Contract no

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40 NAD+, SIRT1, and p63 are all found to decline in aged keratinocytes leading to senescence, 35 while the restoration of NAD+ reduces the senescent cell burden in dermal fibroblasts