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The study confirmed that BPC-157s effects on tube formation were mediated via the ERK1/2 signalling pathway, as its effects were significantly inhibited by the ERK1/2 inhibitor PD98059

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Based on these results, scientists at Tokushima University Hospital and Suzuka University of Medical Science, in Japan, conducted a long-term Phase 2/3 clinical trial (NCT00444613) to evaluate the efficacy and safety of ultra-high-dose methylcobalamin treatment for ALS