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Spermidine-mediated induction of autophagy requires that the pro-autophagic transcription factor identified as TFEB (transcription factor EB, where the EB refers to enhancer box binding site) be activated

These included weight gain, increased weight of visceral organs, and potentially improved feed efficiency when the murine models were exposed to it continuously

Gastroenterology 156 , 10271040.e1023 (2019)

Many groups are at risk for deficiency because their conditions lower the bodys ability to absorb the nutrient when it is consumed