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Furthermore, many patients prescribed tirzepatide for type 2 diabetes are concurrently taking metformin, which independently increases the risk of vitamin B12 deficiency through impaired calcium-dependent B12-intrinsic factor uptake in the ileum

Weight loss depends on starting weight, dosage, individual response, and adherence to diet and exercise recommendations

J Clin Invest 131(12) Schith HB et al (2012) Brain insulin signaling and Alzheimers disease: current evidence and future directions

Glucose-dependent insulinotropic polypeptide (GIP) is the other major incretin hormone (13)

Hormonal Imbalances: Changes in hormone levels, such as during menopause or due to low testosterone, can reduce sexual desire