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[Q] Vikas Shah: I want to come to the lifestyle part in a moment, but when we consider the impact of obesity on diabetes now a massive area of study for you have we really, given the relatively short time GLP-1s have been broadly on the market, understood the impact this is going to have on reducing the medical load of conditions like diabetes and obesity-linked conditions in the future

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BMI above 40 (class 3 obesity) The highest starting BMI group can achieve enormous absolute weight loss with GLP-1 therapy