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Modified or alternative dosage forms will not necessarily eliminate patent or regulatory risk where the same API is used
The honest answer is that DSIPs own pharmacology a plasma half-life measured in minutes in every animal species tested, and reported effects that were explicitly not dose-proportional is the reason no consensus dose ever emerged, and why the numbers circulating online bear little resemblance to the numbers in the studies
Al-Habib A, Al-Radi OO, Shannon P, Al-Ahmadi H, Petrenko Y, Fehlings MG
[DOI] [PubMed] [Google Scholar] 110.Salade L., Wauthoz N., Vermeersch M., Amighi K., Goole J
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