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Indeed, ROS may modulate the NF-B response leading to transcriptional activation of NF-B-target antioxidant genes (e.g., SOD , HO1 , GPX1 , TRX1 , and TRX2 ), which reduce ROS production, thereby promoting cell survival (29) and NF-B-target pro-ROS genes, including NOX2 , COX2 , and NOS2 (29, 32)
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It carries a boxed warning for thyroid C-cell tumors and is not appropriate for patients with a personal or family history of medullary thyroid carcinoma or MEN2