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Our systematic characterization of semaglutides signalling mechanisms in the hindbrain reveals the intracellular signalling architecture through which semaglutide engages cAMP and calcium to regulate body weight, providing avenues for improving obesity therapeutics.

METHODS An electronic search was conducted from June 2024 to July 2024, with an updated search in August 2024, using databases PubMed, PubMed Central, Clinicaltrials.gov, Ovid Medline, and CINAHL

Metformin: Mechanisms in Human Obesity and Weight Loss

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By targeting GLP-1, GIP, and glucagon receptors, researchers are exploring whether multi-pathway therapy can produce deeper metabolic effects than earlier medications