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Inflammatory cytokines including TNF- and interleukin (IL)-1 & Scott et al, 2010) (Figures 5 & 6)
Key findings from the Phase 2 data included: Dose-dependent weight loss : Greater reductions in body weight were observed with higher doses, suggesting a clear pharmacological dose-response relationship
Louradour et al., 2017), activation of the Wingless signaling pathway (Sinenko et al., 2009) and expression of the EBF transcription factor Collier (Benmimoun et al., 2012