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Although there is no close relationship between plasma VPA concentrations and the severity of CNS toxicity [11, 86], patients who ingest more than 200 mg/kg VPA and/or have plasma concentrations greater than 180 g/ml usually develop severe CNS depression

Br J Dermatol 173(6):13871399

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It has been shown to have the capacity to affect several vital functions of the body

What I found in the existing data is that the metabolic improvements from retatrutide, including reduced visceral fat, lower triglycerides, and improved insulin sensitivity, all point toward a cardiovascular benefit profile rather than a risk profile