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e.) achieve therapeutically effective levels of circulating and/or intracellular glutathione using a lower dosage of SAG compared to oral administration of glutathione and/or other glutathione precursors

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The syntheses of this group of ACE inhibitors have been reported via reductive amination of 2-oxo-4-phenylbutyrate, conjugate addition of amines to ethyl-4-oxo-4-phenylcrotonate followed by reduction, S N 2 displacement of ( R )-2-hydroxybutyric acid-derived triflate intermediates by amines and via asymmetric alkylations [145]