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A series of transporters primarily acting in the kidney is responsible for the control of UA in the blood 3 , with URAT1 (coded by SLC22A12) responsible for most kidney reabsorption into the blood and ABCG2 (or breast cancer resistance protein, BCRP) mainly involved in secretion into urine

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Its concentrations are tightly regulated within intracellular compartments to support their diverse functions

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