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Yes, long-term use of proton pump inhibitors (PPIs) such as omeprazole can impair B12 absorption by reducing gastric acid production

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10.3748/wjg.v23.i29.5304 4 DuzelA.VlainicJ.AntunovicM.MalekinusicD.VrdoljakB.SamaraM.et al (2017)

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It's important to note that while these preclinical findings are compelling, human clinical trials remain limited

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