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STOPPFrail is applicable in adults aged 65 or older who meet all the following criteria 37 : End-stage irreversible pathology Poor one year survival prognosis Severe functional or cognitive impairment or both Symptom control is priority rather than preventing disease progression Example criteria include 37 Avoid antiplatelets for primary cardiovascular prevention due to lack of evidence Bisphosphonates are unlikely to be beneficial for short-term osteoporosis treatment Aim for antidiabetic monotherapy with less stringent glycemic control (i.e., hemoglobin A1c goal of less than 8%) End-of-Life Care Prescribers and pharmacists should re-evaluate medications and minimize the pill burden for patients receiving palliative care, particularly at end-of-life (i.e., life expectancy of less than three months)

Sci Rep 7:43212 Meister A, Anderson ME (1983) Glutathione

Journal of Clinical Endocrinology & Metabolism (2006) 4

Studies have shown significant changes in the gut microbiota composition of RA patients, which may contribute to their abnormal systemic immune responses

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