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Upon release, Nrf2 translocates to the nucleus where it can bind to the antioxidant response element (ARE) located in the promoter region of genes coding for antioxidant enzymes and scavengers

By converting APAP into water-soluble forms, this phase II pathway helps detoxify and eliminate APAP from the body, reducing the risk of metabolite accumulation and potential harm

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Tadesse BT, Khanam F, Ahmmed F, Im J, Islam MT, Kim DR, Kang SSY, Liu X, Chowdhury F, Ahmed T, Binte Aziz A, Hoque M, Park J, Pak G, Zaman K, Khan AI, Pollard AJ, Kim JH, Marks F, Qadri F, Clemens JD (2022) Prevention of Typhoid by Vi conjugate vaccine and achievable improvements in household water, sanitation, and hygiene: evidence from a cluster-randomized trial in dhaka, bangladesh

Clin Cancer Res 24(5):1062-1072, 2018