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Early passage ARPE-19 cells were used as a negative control

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Thus, these findings suggest that genistein (and possibly other Nrf-activating agents) coordinately upregulate both the cosubstrate (GSH) and enzyme (GPx-1 or GPx-2) necessary for hydrogen peroxide reduction, thereby contributing to the overall antioxidant capacity of the cell

10.1016/j.parkreldis.2016.08.019 447 VagnerovK.VodikaM.HermanovP.ErgangP.rutkovD.KlusonovP.et al