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3 The result is reduced muscle protein mass and bone density, coupled with increased abdominal fat mass

The MTHFR C677T polymorphism is associated with depressive episodes in patients from Northern Ireland

Larger stones, and stones that fail to pass or cause especially severe pain or obstruction and infection may require more aggressive therapies such as antibiotics, lithotripsy (therapy utilizing ultrasound shock waves to break stones into smaller fragments), or surgery to remove stones (Antonelli 2015)

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(Primary completion November 2025, 68-week treatment period, 4mg/9mg/12mg dose arms