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NHS and BNF recommendations typically include: Oral cyanocobalamin 50150 micrograms daily for dietary deficiency Intramuscular hydroxocobalamin for malabsorption or neurological involvement (initially 1 mg every other day for 1-2 weeks for neurological symptoms, or 1 mg 3 times weekly for 2 weeks without neurological symptoms

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This supports mitochondrial energy production, which becomes more important when calories are lower

There is also no limit on the time that may elapse between a Phase I or Phase II award and a Phase III award, or between a Phase III award and any subsequent Phase III award

[DOI] [PMC free article] [PubMed] [Google Scholar] 398.Taniguchi, S