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Oxidative stress, which increases with age, depletes the levels of glutathione

Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition

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The glucagon component increases energy expenditure and fat oxidation, a mechanism unique to retatrutide that semaglutide (GLP-1 only) and tirzepatide (GLP-1/GIP) lack

The proteins have been identified in numerous redox proteomic data as having a quite large variety of redox PTMs