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Baseline uric acid testing before treatment establishes a reference point for monitoring

In DR, high glucose inhibits Nrf2 activity by activating protein kinase C (PKC) and accumulating advanced glycation end products (AGEs), reducing retinal cell GSH/GPx4 levels, impairing iron export, inducing free iron and LPO accumulation, and activating ferroptosis in Mller, ARPE and endothelial cells, exacerbating vascular leakage (134136)

The GLP-1 agonist was essentially treating allodynia rather than causing it

demonstrated an association between hypoPRLemia and decreased sperm motility (174)

Understanding how GLP-1 therapy influences liver function helps guide appropriate patient selection and monitoring strategies