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Metformin, resveratrol, and exendin-4 inhibit high phosphate-induced vascular calcification via AMPK-RANKL signaling

A case-control study found significantly decreased risk of age-related cataracts (33% to 51%) in men and women in the highest quintile of dietary riboflavin intake (median of 1.6 to 2.2 mg/day) compared to those in the lowest quintile (median of 0.08 mg/day in both men and women) (33)

This means for those who cannot get in enough calcium from food it is not unreasonable to use supplements, but they must be taken directly with the meals, not in between or fasting

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However, these powerful medications come with several side effects and potential risks