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Orlistat 60 mg (the Alli dose) specifically showed an even smaller average weight loss of 5.5 pounds (2.5 kg) compared to the placebo group

Recent studies have found that increased level of GLP-1 in the hippocampus restores GABA and reverses this neurotoxic effect by reducing oxidative stress through the SIRT1/Nrf2/HO-1 pathway, promoting autophagy through the AMPK/mTOR pathway, and alleviating hippocampal apoptosis by inactivating pro-apoptotic kinase GSK-3 (Nrgaard et al., 2022)

Additionally, compression may play a role too

doi: 10.1016/j.biopsych.2014.10.014 17 BoldriniM.UnderwoodM

And now this is important because if you stimulate insulin secretion, blood glucose will go down