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In the SURPASS-2 trial, patients with obesity and T2D who received tirzeapatide (5 mg weekly) achieved greater HbA1c and body weight reductions than those receiving semaglutide (1 mg weekly) during the 40 week study (64) despite comparable putative GLP-1R occupancy at these doses (47)

Retrieved March 10, 2026, from 21 Missouri Department of Social Services

These medications are highly effective, often leading to significant health improvements with minimal side effects

The 2012 weight loss trial in fibromyalgia found significant pain reductions with weight loss

Some medications may benefit from reaching room temperature before injection to reduce discomfort, but this varies by productcheck your medication's Instructions for Use (IFU)